PRAGUE (November 14th, 2010): The Azacycles company (Kladno, Czech Republic) introduced first generation of highly effective nanocarriers like a matrixes of nanobots of the new concept or idea. Present nanocarriers have plenty of disadvantages. Hitherto published principles of nanocarriers also do not adequately deal with the encapsulation of peptides >5 kDa, lyophilization of encapsulated active ingredients in the form of the resulting nanoparticle, modularity of bio-distribution of active ingredients by structural modifications of the nanocarrier (pharmacokinetic and pharmacodynamic parameters), resistance of the nanocarrier to the effect in the human organism of highly distributed extracellular lipases and proteo-lipases, in many cases of toxic products the removal of polymer chains of nanocarriers whether of typical xenobiotics or processes part of the organism but that are adverse producing compounds (a typical representative being lactate released from the removal of lactate hydrophilic polyesters which trigger strongly anti-inflammatory processes in places of affected cells as a result of the natural reaction of the organism to endogenous lactate). The fundamental lack of all self-assembly nanocarriers is the thermal and chemical lability and the resulting limitation in terms of storage, sterilization, drying, type of placed ingredients and unfortunately and above all limited stability in the extracellular environment of the organism. This is the price of the very low cost of production of these supra-molecular noncovalent structures.
The Azacycles' nanobots or nanocarriers show rare parameters so hopefully they will be introduced into building of future drugs and pharmaceuticals.
The Azacycles' nanobots or nanocarriers show rare parameters so hopefully they will be introduced into building of future drugs and pharmaceuticals.
