Azacycles company introduces intelligent nanobots of the 1st generation

PRAGUE (July 18th, 2011): The first generation of an intelligent nanocarriers, so called nanobots has been introduced by Azacycles (Kladno, Czech Republic). The final technology crosses into its second generation phase. What are the benefits of the technology? The nanobots are created by hollow highly hydrophilic spherical nanoparticles with polysaccharide fully covalent skeletons. The technology allows the production of hollow spherical nanoparticles of the following parameters: outer diameter ranging from 35 – 20000 nm,
mono to trimolecular thickness of the skeleton wall, high sphericity index approaching 1, polydispersity index approaching 1, diffusion holes according to the used synthesis components ranging from 0.1 – 4.5 nm2,
levels of radial and diagonal cross-links ranging from 1.5 – 3.0, extraordinarily broad scope of biodegradability and metabolisability in the organism according to the used structure of saccharide units and method of their covalent link (e.g. type of glycoside). The products of metabolisation in the extracellular environment are only saccharides and oligosaccharides, selective functionalizability of the inner and outer wall in the production process (so-called nanoparticles may have specific functional groups or reactive groups directed (protruding) inside the cavity).

New generation of nanobots has been introduced by Azacycles

PRAGUE (November 14th, 2010): The Azacycles company (Kladno, Czech Republic) introduced first generation of highly effective nanocarriers like a matrixes of nanobots of the new concept or idea. Present nanocarriers have plenty of disadvantages. Hitherto published principles of nanocarriers also do not adequately deal with the encapsulation of peptides >5 kDa, lyophilization of encapsulated active ingredients in the form of the resulting nanoparticle, modularity of bio-distribution of active ingredients by structural modifications of the nanocarrier (pharmacokinetic and pharmacodynamic parameters), resistance of the nanocarrier to the effect in the human organism of highly distributed extracellular lipases and proteo-lipases, in many cases of toxic products the removal of polymer chains of nanocarriers whether of typical xenobiotics or processes part of the organism but that are adverse producing compounds (a typical representative being lactate released from the removal of lactate hydrophilic polyesters which trigger strongly anti-inflammatory processes in places of affected cells as a result of the natural reaction of the organism to endogenous lactate). The fundamental lack of all self-assembly nanocarriers is the thermal and chemical lability and the resulting limitation in terms of storage, sterilization, drying, type of placed ingredients and unfortunately and above all limited stability in the extracellular environment of the organism. This is the price of the very low cost of production of these supra-molecular noncovalent structures.

The Azacycles' nanobots or nanocarriers show rare parameters so hopefully they will be introduced into building of future drugs and pharmaceuticals.